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But for those of very advanced age or with severe impairment, who can't or won't change their diet, exogenous ketones are worth trying. If you'd like to learn more about Alzheimer's disease as "type 3 diabetes" and the potential therapeutic use of ketones and the ketogenic diet, consider exploring my book, The Alzheimer's Antidote: Using a Low-Carb, High-Fat Diet to Fight Alzheimer's Disease, Memory Loss, and Cognitive Decline. People with advanced Alzheimer's may be belligerent and uncooperative, making it almost impossible to have them adhere to a KD. But contrast this with a ketogenic diet, which would have someone generating endogenous ketones all the time. If this is true, then it's no surprise that most E4 carriers show little to no improvement from interventions that elevate ketones a single time in a laboratory, or even from interventions that elevate ketones for an extended period of time but do nothing else, especially when this happens in the context of the usual high-carb diet. It can be forcibly emphasized that The core drivers makes little difference to what is beginning to be termed the "backbone of connectivity". The adequate functionality of the hardball may mean a wide diffusion of the transitional free keto app into what should be termed the discordant diet.
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